Non-enzymatic electroanalytical sensing of glucose based on nano nickel-coordination polymers-modified glassy carbon electrode

Amir Reza Abbasi, Mohammadreza Yousefshahi, Kim Daasbjerg

Herein, we introduce a simple set of experiments to construct non-enzymatic glucose sensors. The modification procedure was initiated by electrodeposition of nickel-coordination polymers (denoted henceforth as Ni-CPs) at the surface of glassy carbon (GC) electrode decorated with carbonnanotubes (CNTs). The electrochemical sensing of glucose occurred through the electrocatalytic oxidation of glucose by the Ni-CP using the CNTs as a high-area catalyst support. During potential cycling, the continuous chemical regeneration of the Ni(II) in the reaction between Ni(III) and glucose expresses itself as a dramatic enhancement of the anodic current pertaining to the Ni(III)/Ni(II) redox couple. Effects of various factors such as scan rate and solution pH were evaluated. For the optimized sensor the detection limit was as low as 2.1 μM glucose and with a linear response extending up to 400 μM. The modified electrode showed good reproducibility, excellent anti-interference performance, and high stability during the electrochemical experiments. Moreover, the analytical function of the non-enzymatic sensors for quantitative detection of glucose was assessed in real samples with satisfying results.